British Science Festival 2018

Last week I attended the British Science Festival run by the British Science Association, this year at Hull University. It was a week of wonder for all those interested in the world around them. From the secrets of the canine mind to using waste aluminium to capture carbon, there was something for everyone at this years festival.

I was fortunate enough to be attending the festival as a press intern, which meant reporting on all things festival. The experience itself was inspiring but better than that, it was an opportunity to learn.

Out of the many scientific revelations I discovered over the week one of the most interesting to me was about the future of medical technology. I was given the opportunity to write a blog post on my findings so I thought I’d share that with you this week. If you’re interested in hearing about other festival events and activities don’t forget to check out the British Science Associations website!

So here goes…

British Science Festival – The robot will see you now: the future of medical technology

by Alicia Shephard, British Science Festival

From iPads to space travel, robots to facetime, many of the predictions of A 2001 Space Odyssey have materialised in society over the past 50 years. However, one prediction you might have missed is metabolic monitoring during intensive care. This is something which is soon to become a reality thanks to the pioneering work of British Science Festival Award Lecture, Gemma Bale.

Gemma’s research is helping advance diagnosis techniques for the baby brain injury known as Hypoxic Ischemic Encephalopathy (HIE), a type of brain damage which occurs when a baby’s brain doesn’t receive enough oxygenated blood.

Due to the nature of the disease, it requires immediate medical attention including an MRI scan. However, the MRI can’t be performed until the infant is a week old, leaving a large window of time for the babies’ condition to worsen.

All hope is not lost though thanks to CYRIL, a machine which is capable of using colour to identify oxygen and metabolic levels within the brain. This is enabled by the translucent property of our own body which allows red light to pass through and be absorbed by oxygenated blood cells and the enzyme responsible for using oxygen in our metabolism. This light then ‘bounces back’ for detection and is converted into measurable metabolic and oxygen levels in the brain.

The levels of these components is highly coupled with the severity of brain injury. Therefore, this research could lead to identification of brain injury before an MRI scan would occur, ultimately resulting in more rapid, specialised treatment for the infant.

So, a 50-year old prediction is finally making its way into medical technology. But what do the next 50 years hold for us? Artificial intelligence is likely to hold a lot of the answers we’re looking for.

While it might sound like scary stuff, artificial intelligence is far from it. It simply means the ability of a computer to perform a task that usually requires human intelligence. If you really boil it down, something as simple and commonplace as a calculator could be considered artificial intelligence. Not so scary now is it?

A pathologist at work (Picture: JBSA, Staff Sgt. Jerilyn Quintanilla)

As Darren Treanor, a consultant pathologist explained at The robot will see you now event: “Artificial intelligence is used in all aspects of computer science and in recent years it has become much better at doing what we can do.”

This improvement is largely thanks to new techniques of teaching computers. Rather than using standard algorithms we now use deep conditioning methods which require vast amounts of data but are far more effective.

The use of artificial intelligence within pathology is a growing field of research. Between 2009 and 2016 the number of people waiting for a diagnosis doubled and there simply aren’t enough pathologists to do the job. Whilst it’s unlikely artificial intelligence could replace the experts altogether, they could rapidly decrease wait times and improve accuracy of diagnosis.

An experiment surrounding the precision of pathologist’s diagnosis found that, when given unlimited time to detect tumours from samples of tissue, the experts were able to do so with at least 95% precision. However, when asked to complete the same task with only a minute per sample, the accuracy dropped dramatically to as low as 50%. Pathologists experience pressure just like this on a daily basis. The advantage of using artificial intelligence is that it doesn’t experience these same pressures but is still capable of achieving the same results.

The overriding consensus is this: a computer can make a diagnosis much faster than a human, and has the advantage of being unaffected by health, fatigue and emotional influences. But any work it does should always be monitored by an actual person.

Now that all sounds very reassuring, but what about the dangers of artificial intelligence getting it wrong? Not to worry: pathologists, software engineers and artificial intelligence experts alike agree that this technology should not be used alone. In its current state it’s a method of increasing rates of diagnosis.

Who knows what predictions we’ll be making in 50 years’ time, but for now improving diagnosis through innovative technology and artificial intelligence appears to be the path to take.

BIOLOGEEKS IS BACK

Kelp_Forests,_National_Museum_of_Marine_Biology_and_Aquarium_20130825.jpgBiologeeks is back! Sadly, I had to take a little break because I was studying for my undergraduate degree in Zoology and that ultimately took over my life a little. Thankfully the short break was worth it however, as I am now the proud owner of a Bachelor of Science, making myself further qualified to dissect all things biological.

Seeing as the academic year has just begun this seemed like the perfect time to put Biologeeks back into action. I’ll still be covering all aspects of biology, and the fact of the week is not going to disappear anytime soon, but there will be some exciting new developments happening so keep your eyes peeled.

If you just cant wait for that next glimpse into the biological world then check out my older posts. I look forward to creating a world of biologeeks with you!

A Breath of Not-So-Fresh Air: are e-cigarettes worse for us than we first thought?

Whilst smoking has long been a contentious issue in both science and society it is no secret that it is undoubtedly bad for you.  Despite this, many continue to smoke thanks to the addictive properties possessed by nicotine, a primary component of cigarettes.

Then in 2003 E-cigarettes were invented by a Chinese pharmacist. These electronic aids revolutionised the way we as a society smoke, and they quickly became popular especially with younger people.

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E-cigarettes work by delivering nicotine to the body as an aerosol, without the aid of tobacco or the burning process. Ordinarily when the burning process happens, it causes the incomplete burning of more than 7000 carcinogenic* compounds found in the cigarette. Since E-cigarettes don’t contain these compounds it was no wonder that they rapidly gained support and were promoted as safe.

However, a team of researchers at the New York university School of Medicine have discovered some disturbing consequences of the nicotine in e-cigarettes in a study they conducted on mice. Once inside the body, nicotine was found to undergo a transformation into substances which can damage DNA and lead to cancerous mutations.

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Furthermore, the nicotine was found not only to induce cancer, but also to reduce repair activity within the vital organs of the mouse including the lung, heart and bladder. As the study was conducted on mice, which are obviously not humans, it’s easy to dissociate ourselves from this study, however, the scientists also concluded that the same damage was caused to a group of cells taken from a human lung and bladder.

It can take decades for carcinogenics to induce cancer in humans and, as e-cigarettes are a relatively new phenomenon, it could be years before there are applicable results from a human study. Despite this, the results presented by these scientists show some evidence of e-cigarette smoke being dangerous for human health and increasing the risk of developing different cancers and heart disease.

Glossary
Carcinogen – A substance capable of causing cancer

Reference
Lee, H., Park, S., Weng, M., Wang, H., Huang, W., Lepor, H., Wu, X., Chen, L. and Tang, M. (2018). E-cigarette smoke damages DNA and reduces repair activity in mouse lung, heart, and bladder as well as in human lung and bladder cells. Proceedings of the National Academy of Sciences, 115(7), pp.E1560-E1569.

Fact Of The Week

When we get cold we get goosebumps but these aren’t actually of any use to us now, they’re left over from our evolutionary ancestors. They occur when muscles at the base of each hair tense, making the hair stand up. If we had a decent covering of fur or hair this would allow air to get trapped and insulate us. However, human hair is too thin so this doesn’t work for us!

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Keeping Future Hearts Beating

The heart is a crucial organ for an embryo to progress past 10 weeks old, without it the circulatory system collapses.  Problems with the way the heart beats are known as ‘Arrhythmias’ and these can be just as lethal.

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These heart rhythm problems effect approximately 2 million people annually in the UK. There’s a variety of different types, some of which people can lead a normal life if properly diagnosed but if left untreated can cause serious cardiac issues.

A normal healthy heart contracts from the top down at roughly 80 beats per minute. In a heart with a conduction disorder, like arrhythmias, the heart rate can be faster than normal, slower than normal, more irregular or a combination of these.

One way to treat Arrhythmias is with a pacemaker. This is a medical device which is implanted into the chest to control the rhythm of the heart using low energy electrical impulse to encourage a normal heartbeat.

Pacemakers are usually composed of a generator and battery attached to leads inside the heart. The first fully implantable pacemaker was made 60 years ago and supported the patient’s heart rhythm for 3 hours then had to be replaced by a new device.

Since then technology has come a long way and this has resulted in a smaller device with improved functionality thanks to adjustments made to generator size, battery life and lead design. Modern pacemakers can provide a stable heart beat for 10 years before having to be changed.

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The next generation of pacemakers have two issues to tackle: increasing battery life and having an automatic, involuntary response to the functions of the heart. There is already research into using solar energy to power the pacemakers but more options need to be investigated.

A possible alternative to the electronic pacemaker is the biological pacemaker. These are being produced in different ways. Gene-based approaches made a biological pacemaker in 2002 which was tested on Guinea pigs, it stimulated the release of an electrical current over the muscle cells of the lower heart.

Similarly, cell- based approaches have also been used. This requires a cluster of randomly beating cells to be transplanted into the heart to generate pacemaker activity. There has even been some investigation into using a combination of both gene and cell based approaches, for example, the delivery of cells carrying pacemaker genes into the heart.

Up to now, the delivery methods of biological pacemakers on large animals has required open chest surgery which Is highly invasive and therefor limits the potential for simply repeating it in humans. However, with over 200,000 patients a year undergoing permanent pacemaker implantation it is clear an alternative is needed and biological pacemakers could be just that.